Description

MOTS-c is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S ribosomal RNA gene. Unlike traditional hormones, MOTS-c acts as a “mitokine,” translocating to the nucleus in response to metabolic stress to regulate nuclear gene expression. In laboratory research, it is the primary entity for investigating the mitochondrial-nuclear communication axis and its impact on systemic metabolism and cellular aging.

 

Performance Peptides Canada provides MOTS-c 40mg vials at 99%+ HPLC-verified purity. Our domestic Canadian fulfillment ensures that this sensitive metabolic regulator is shipped with speed and climate integrity for advanced mitochondrial research.

Technical Specifications & Chemical Profile

Our MOTS-c is synthesized to the following analytical benchmarks:

• Molecular Formula: C₇₈H₁₃₈N₂₆O₂₄S₂
• Molecular Weight: 2174.6 g/mol3
• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Met-Cys-Ser-Ser-Asp-Ala
• Purity: ≥99.0% (Verified via HPLC/MS)
• CAS Number: 1627580-64-64
• Form: Lyophilized white powder

Primary Research Mechanisms & Metabolic Regulation

MOTS-c is studied for its unique ability to mimic the beneficial effects of exercise at a cellular level.

1. AMPK Activation & Glucose Metabolism

MOTS-c is a potent activator of the AMP-activated protein kinase (AMPK) pathway. By increasing the levels of AICAR (an intermediate in the purine salvage pathway), MOTS-c enhances glucose uptake in skeletal muscle and inhibits gluconeogenesis in the liver. Researchers utilize this peptide to study the restoration of insulin sensitivity and the reversal of diet-induced metabolic dysfunction.

2. Mitochondrial-Nuclear Translocation

Under conditions of metabolic stress (such as exercise or nutrient deprivation), MOTS-c translocates from the mitochondria to the nucleus. There, it interacts with ARE (Antioxidant Response Element)-containing genes to regulate the cellular stress response. This unique “retrograde signaling” is a vital area of study for researchers interested in mitohormesis and genomic stability.

3. Fatty Acid Oxidation & Thermogenesis

Research indicates that MOTS-c promotes the beta-oxidation of fatty acids and influences the “browning” of white adipose tissue. By upregulating UCP1 (Uncoupling Protein 1), it is studied for its role in increasing thermogenesis and whole-body energy expenditure, making it an essential tool for obesity and lipid metabolism research.

Reconstitution & Stability Benchmarks

As a mitochondrial-derived peptide, MOTS-c is highly sensitive to pH and temperature:

• Reconstitution: Recommended diluent is Bacteriostatic Water or 0.9% Sterile Saline.
• Solubility: MOTS-c is generally well-dissolved in aqueous solutions, but may require gentle swirling. Do not shake, as mechanical stress can lead to peptide aggregation.
• Storage: Store lyophilized powder at -20°C. Once reconstituted, store at 2°C to 8°C.

Stability Data

Storage Condition	Physical State	Estimated Stability
-20°C (Freezer)	Lyophilized (Dry)	24+ Months
2°C to 8°C (Fridge)	Lyophilized (Dry)	12 Months
2°C to 8°C (Fridge)	Reconstituted	5–7 Days

Note: For maximal potency in research, it is recommended to use MOTS-c shortly after reconstitution, as mitochondrial peptides can be more susceptible to enzymatic degradation than standard signaling peptides.

MOTS-c Research FAQ

Q: Is MOTS-c considered an “exercise mimetic”?

A: Yes. In research models, MOTS-c has been shown to produce metabolic changes similar to those induced by aerobic exercise, including improved glucose disposal and increased mitochondrial biogenesis.

 

Q: What is the purity of your MOTS-c?

A: Every batch of MOTS-c 40mg from Performance Peptides Canada is verified to be 99% pure or higher via HPLC and Mass Spectrometry.

 

Q: Why is domestic Canadian shipping important for MOTS-c?

A: MOTS-c is a complex peptide that requires stable environmental conditions. Shipping from within Canada avoids the extreme temperature fluctuations and customs delays that can occur with international orders, ensuring the peptide arrives in its most active form.