Description

Thymosin Alpha-1 Biovantage Labs Research Peptide

Thymosin Alpha-1 is a 28-amino acid peptide derived from prothymosin alpha, studied for its immunomodulatory properties including T-cell differentiation, dendritic cell maturation, and innate immune signalling. Biovantage Labs supplies Thymosin Alpha-1 at 99+% purity, verified by batch-specific HPLC and Mass Spectrometry. Domestically fulfilled from Canada. Not for human consumption. Biovantage Labs provides this compound at 99+% purity, confirmed by batch-specific HPLC and Mass Spectrometry analysis, as a lyophilized compound for use in controlled laboratory settings.

Molecular Profile and Chemical Specifications

Specification	Detail
Molecular Formula	C129H215N33O55
Molecular Weight	3,108.3 Da
Purity	≥99+% (HPLC/MS verified)
Physical Form	Lyophilized white powder
CAS Number	62304-98-7

 

Primary Research Mechanisms

T-Cell Differentiation and Maturation

Thymosin Alpha-1 is studied for its role in promoting the maturation and differentiation of T-lymphocyte precursors within thymic tissue models. Research has examined its influence on both CD4+ and CD8+ T-cell subpopulation development.

Despite sharing the thymosin family designation, TB-500 (Thymosin Beta-4 Fragment) is structurally and functionally distinct, studied primarily for actin regulation and tissue remodelling rather than lymphocyte biology, and represents a separate research axis within the broader thymosin peptide class.

Toll-Like Receptor (TLR) Signalling

In innate immune research, Thymosin Alpha-1 has demonstrated activation of Toll-Like Receptor pathways (particularly TLR2 and TLR9), stimulating dendritic cell maturation and natural killer cell activity in preclinical models.

Autophagy Induction Research

Thymosin Alpha-1 has been investigated in the context of autophagy, the cellular self-degradation process as a mechanism relevant to intracellular pathogen clearance in macrophage research models.

Researchers studying immune tolerance induction may also examine VIP (Vasoactive Intestinal Peptide), which promotes regulatory T-cell differentiation and Th1/Th17 suppression through a distinct VPAC receptor-mediated mechanism.

Reconstitution Protocol

• Reconstitute using sterile bacteriostatic water or 0.9% sodium chloride solution
• Introduce diluent slowly along the interior vial wall do not inject directly onto the lyophilized cake
• Swirl gently until fully dissolved do not shake or vortex
• Allow the vial to equilibrate to room temperature before opening to prevent condensation

Storage and Stability

Storage Condition	State	Estimated Stability
-20°C to -80°C	Lyophilized	24+ months
2°C to 8°C	Lyophilized	12 months
Room temperature (20°C)	Lyophilized	3 months
2°C to 8°C	Reconstituted	7 to 14 days

 

Store in a desiccated environment away from UV exposure. Avoid repeated freeze-thaw cycles, which degrade peptide chain integrity over time.

Thymosin Alpha-1 Research FAQ

Q: How is Thymosin Alpha-1 different from Thymosin Beta-4 (TB-500)?

A: Thymosin Alpha-1 and Thymosin Beta-4 are structurally and functionally distinct peptides despite sharing the thymosin family designation. Thymosin Alpha-1 is studied primarily for immunomodulatory effects on T-cell and dendritic cell systems. Thymosin Beta-4 (TB-500) is studied for actin sequestration and tissue remodelling. Their research applications are largely separate.

Q: Is Thymosin Alpha-1 for human use?

A: No. Thymosin Alpha-1 supplied by Biovantage Labs is strictly for laboratory research purposes. It is not approved for human consumption, veterinary use, or clinical application.

Q: What purity standard does Biovantage Labs apply?

A: Every batch is verified at 99+% purity using HPLC to confirm compound concentration and Mass Spectrometry to confirm molecular identity. Batch-specific COA documentation is available upon request.

Q: Where does Biovantage Labs ship from?

A: All Biovantage Labs products are fulfilled domestically from within Canada, eliminating customs clearance risk and reducing transit time compared to international suppliers.