Description

TB-500 Biovantage Labs Research Peptide

TB-500 (Thymosin Beta-4 Fragment) is a synthetic analogue of the naturally occurring peptide Thymosin Beta-4, studied for its role in actin regulation, cellular migration, and tissue remodelling research. Biovantage Labs supplies TB-500 at 99+% purity, verified by batch-specific HPLC and Mass Spectrometry, as a lyophilized research compound for laboratory use. Domestically fulfilled from Canada. Not for human consumption. Biovantage Labs provides this compound at 99+% purity, confirmed by batch-specific HPLC and Mass Spectrometry analysis, as a lyophilized compound for use in controlled laboratory settings.

Molecular Profile and Chemical Specifications

Specification	Detail
Molecular Formula	C212H350N56O78S
Molecular Weight	4,963.5 Da
Purity	≥99+% (HPLC/MS verified)
Physical Form	Lyophilized white powder
CAS Number	77591-33-4

 

Primary Research Mechanisms

Actin Sequestration and Cytoskeletal Regulation

TB-500 binds G-actin monomers with high affinity, modulating the actin polymerization equilibrium. This mechanism is studied in the context of cytoskeletal dynamics, cell motility, and the regulation of wound healing at the cellular level.

TB-500 is frequently examined alongside BPC-157 in tissue repair research models; the two compounds target distinct upstream nodes (actin sequestration vs. FAK-paxillin pathway) and are studied both independently and in parallel protocols examining convergent repair mechanisms.

Upregulation of Cell Migration via Thymosin Beta-4 Pathway

As a functional fragment of Thymosin Beta-4, TB-500 is examined for its role in promoting keratinocyte and endothelial cell migration processes fundamental to wound closure and tissue remodelling research models.

Anti-Inflammatory Signalling

TB-500 has been investigated in inflammatory research models for its capacity to modulate cytokine expression. Studies have examined its interaction with NF-kB signalling pathways as part of broader inflammatory resolution research.

Angiogenesis and Vascular Remodelling

In vascular research contexts, TB-500 has demonstrated pro-angiogenic properties through promotion of endothelial cell differentiation and tubule formation, representing an area of active investigation in ischaemic tissue models.

Researchers working within the broader thymosin peptide class may also reference Thymosin Alpha-1, which shares the thymosin designation but is studied primarily for immunomodulatory rather than cytoskeletal properties.

Reconstitution Protocol

• Reconstitute using sterile bacteriostatic water or 0.9% sodium chloride solution
• Introduce diluent slowly along the interior vial wall. Do not inject directly onto the lyophilized cake
• Swirl gently until fully dissolved. Do not shake or vortex
• Allow the vial to equilibrate to room temperature before opening to prevent condensation

Storage and Stability

Storage Condition	State	Estimated Stability
-20°C to -80°C	Lyophilized	24+ months
2°C to 8°C	Lyophilized	12 months
Room temperature (20°C)	Lyophilized	3 months
2°C to 8°C	Reconstituted	7 to 14 days

 

Store in a desiccated environment away from UV exposure. Avoid repeated freeze-thaw cycles, which degrade peptide chain integrity over time.

TB-500 Research FAQ

Q: How does TB-500 differ from BPC-157 in research models?

A: TB-500 and BPC-157 operate through distinct primary mechanisms. TB-500 primarily acts via actin sequestration and cytoskeletal modulation, while BPC-157 targets the FAK-paxillin pathway and nitric oxide system. Both are studied in tissue repair contexts but address different upstream regulatory nodes.

Q: Is TB-500 for human use?

A: No. TB-500 supplied by Biovantage Labs is strictly for laboratory research purposes. It is not approved for human consumption, veterinary use, or clinical application.

Q: What purity standard does Biovantage Labs apply?

A: Every batch is verified at 99+% purity using HPLC to confirm compound concentration and Mass Spectrometry to confirm molecular identity. Batch-specific COA documentation is available upon request.

Q: Where does Biovantage Labs ship from?

A: All Biovantage Labs products are fulfilled domestically from within Canada, eliminating customs clearance risk and reducing transit time compared to international suppliers.