Description

PT-141 (Bremelanotide) – 10mg Lyophilized Powder

PT-141 is a synthetic peptide analogue of α-MSH (alpha-Melanocyte-stimulating hormone). Unlike traditional phosphodiesterase-5 (PDE5) inhibitors that act on the vascular system, PT-141 is researched for its unique mechanism of action within the central nervous system. It acts as a non-selective agonist of the melanocortin receptors (primarily MC3R and MC4R), making it a primary reagent for studying the neurological triggers of sexual dysfunction and hemorrhagic shock in vivo.

Technical Specifications

Melanocortin Receptor Activation and CNS Signaling

The primary focus of PT-141 research is its bypass of the cardiovascular system. By binding to MC4R receptors in the hypothalamus, PT-141 is studied for its ability to trigger excitatory neural pathways. Research models utilize this peptide to observe the modulation of dopamine release and its subsequent effects on libido and arousal. Furthermore, PT-141 is investigated for its potential “cytoprotective” properties during ischemia/reperfusion injury, as melanocortin signaling has shown promise in reducing systemic inflammatory responses.

Handling Protocols for Research Stability

To ensure the analytical integrity of PT-141, the reagent must be protected from thermal degradation.

• Reconstitution: Use sterile bacteriostatic water. Gently swirl the vial; do not shake, as vigorous agitation can lead to the denaturation of the peptide chain.
• Stability: Once reconstituted, the solution should be stored at 2°C–8°C and used within 14–21 days.
• Shipping: Performance Peptides Canada ships all PT-141 in vacuum-sealed, lyophilized vials to ensure 100% molecular stability during domestic transit.