Description

HGH – Biovantage Labs Research Peptide

HGH (Human Growth Hormone / Somatotropin) is a 191-amino acid polypeptide studied for its pleiotropic metabolic effects including IGF-1 axis activation, lipolysis, protein synthesis stimulation, and carbohydrate metabolism modulation in preclinical research models. Biovantage Labs supplies HGH in 10iu and 15iu configurations at 99+% purity, HPLC/MS verified. Domestically fulfilled from Canada. Not for human consumption. Biovantage Labs provides this compound at 99+% purity, confirmed by batch-specific HPLC and Mass Spectrometry analysis, as a lyophilized compound for use in controlled laboratory settings.

Molecular Profile and Chemical Specifications

Specification	Detail
Molecular Formula	C990H1529N263O299S7
Molecular Weight	22,124 Da
Structure	191 amino acid single-chain polypeptide (2 disulfide bonds)
Purity	≥99+% (HPLC/MS verified)
Physical Form	Lyophilized white powder
Available Configurations	10iu / 15iu

 

Selecting the Correct Research Configuration

Configuration	Typical Research Application
10iu	Shorter-duration protocols, dose-response studies, introductory GH axis research
15iu	Extended GH axis protocols, multi-parameter metabolic studies, larger animal models

 

Primary Research Mechanisms

GH Receptor Activation and JAK2-STAT5 Signalling

HGH binds the growth hormone receptor (GHR) in a 1:2 stoichiometry, triggering receptor dimerisation and activation of JAK2 kinase. Research examines downstream STAT5 phosphorylation and nuclear translocation as the primary transcriptional mechanism mediating GH’s anabolic effects.

A significant portion of HGH’s downstream anabolic effects are mediated through hepatic IGF-1 production. Research designs examining this axis frequently include IGF-1 LR3 as a direct IGF-1 receptor agonist tool, allowing comparison of endogenous IGF-1 stimulation (via HGH) against direct receptor engagement.

IGF-1 Production and the GH/IGF-1 Axis

HGH stimulates hepatic IGF-1 synthesis, the principal mediator of GH’s growth-promoting effects in peripheral tissues. Research using HGH in conjunction with IGF-1 measurement allows complete characterisation of the GH/IGF-1 axis in experimental models.

Direct Metabolic Effects – Lipolysis and Gluconeogenesis

Independent of IGF-1, direct GH action on adipocytes stimulates lipolysis and free fatty acid mobilisation. Simultaneously, HGH exerts anti-insulin effects on glucose metabolism via downregulation of insulin receptor substrate signalling both mechanisms studied in metabolic research models.

For research specifically focused on the lipolytic properties of the growth hormone axis without full GHR activation, AOD-9604, the C-terminal fragment of HGH, is studied as a more selective research tool targeting beta-3 adrenergic receptor-mediated lipolysis.

Reconstitution Protocol

•       Reconstitute using sterile bacteriostatic water or 0.9% sodium chloride solution
•       Introduce diluent slowly along the interior vial wall do not inject directly onto the lyophilized cake
•       Swirl gently until fully dissolved do not shake or vortex
•       Allow the vial to equilibrate to room temperature before opening to prevent condensation

Storage and Stability

Storage Condition	State	Estimated Stability
-20°C to -80°C	Lyophilized	24+ months
2°C to 8°C	Lyophilized	12 months
Room temperature (20°C)	Lyophilized	3 months
2°C to 8°C	Reconstituted	7 to 14 days

 

Store in a desiccated environment away from UV exposure. Avoid repeated freeze-thaw cycles, which degrade peptide chain integrity over time.

HGH Research FAQ

Q: Why is HGH measured in international units (IU) rather than milligrams?

A: Growth hormone potency is conventionally expressed in international units based on biological activity standardised against a WHO reference preparation, rather than mass alone. This is because manufacturing processes produce HGH with varying specific activities. For research purposes: 1 mg of pharmaceutical-grade HGH is approximately equivalent to 3iu, though this ratio varies by preparation and purity.

Q: Is HGH for human use?

A: No. HGH supplied by Biovantage Labs is strictly for laboratory research purposes. It is not approved for human consumption, veterinary use, or clinical application.

Q: What purity standard does Biovantage Labs apply?

A: Every batch is verified at 99+% purity using HPLC to confirm compound concentration and Mass Spectrometry to confirm molecular identity. Batch-specific COA documentation is available upon request.

Q: Where does Biovantage Labs ship from?

A: All Biovantage Labs products are fulfilled domestically from within Canada, eliminating customs clearance risk and reducing transit time compared to international suppliers.