Description

Ipamorelin – Biovantage Labs Research Peptide

Ipamorelin is a selective pentapeptide growth hormone secretagogue studied for its specific stimulation of pituitary GH release via the ghrelin receptor (GHS-R1a), with research noting selectivity that avoids significant co-stimulation of ACTH, cortisol, or prolactin. Biovantage Labs supplies Ipamorelin at 99+% purity, HPLC/MS verified. Domestically fulfilled from Canada. Not for human consumption. Biovantage Labs provides this compound at 99+% purity, confirmed by batch-specific HPLC and Mass Spectrometry analysis, as a lyophilized compound for use in controlled laboratory settings.

Molecular Profile and Chemical Specifications

Specification	Detail
Molecular Formula	C38H49N9O5
Molecular Weight	711.9 Da
Sequence	Aib-His-D-2Nal-D-Phe-Lys-NH2
Purity	≥99+% (HPLC/MS verified)
Physical Form	Lyophilized white powder
CAS Number	170851-70-4

 

Primary Research Mechanisms

Selective GHS-R1a Agonism

Ipamorelin binds the ghrelin receptor (GHS-R1a) with high selectivity, stimulating GH release from pituitary somatotrophs. Research highlights its selectivity profile relative to older GH secretagogues such as GHRP-6, which co-stimulate cortisol and ACTH pathways at equivalent doses.

The most studied dual-agonist pairing in GH secretagogue research combines Ipamorelin with CJC-1295 with DAC, Ipamorelin engaging GHS-R1a and CJC-1295 engaging the GHRH receptor simultaneously to investigate additive effects on GH pulse amplitude that neither compound produces alone at equivalent doses.

Preservation of Pulsatile GH Architecture

Unlike continuous GH infusion models, Ipamorelin research indicates it preserves the physiological pulsatile pattern of GH secretion. This property is examined in protocols studying the relationship between GH pulse architecture and downstream IGF-1 expression.

Combination Research with GHRH Analogues

Ipamorelin is frequently studied in combination with GHRH analogues such as CJC-1295. The dual-agonist approach targeting both the GHRH receptor and GHS-R1a simultaneously is examined for its synergistic effects on GH secretion amplitude in animal models.

Research protocols using Ipamorelin to stimulate endogenous GH secretion are often designed alongside direct HGH (Human Growth Hormone) administration studies to compare stimulated versus exogenous GH delivery on downstream IGF-1 expression and metabolic outcomes.

Reconstitution Protocol

• Reconstitute using sterile bacteriostatic water or 0.9% sodium chloride solution
• Introduce diluent slowly along the interior vial wall do not inject directly onto the lyophilized cake
• Swirl gently until fully dissolved do not shake or vortex
• Allow the vial to equilibrate to room temperature before opening to prevent condensation

Storage and Stability

Storage Condition	State	Estimated Stability
-20°C to -80°C	Lyophilized	24+ months
2°C to 8°C	Lyophilized	12 months
Room temperature (20°C)	Lyophilized	3 months
2°C to 8°C	Reconstituted	7 to 14 days

 

Store in a desiccated environment away from UV exposure. Avoid repeated freeze-thaw cycles, which degrade peptide chain integrity over time.

Ipamorelin Research FAQ

Q: Why is Ipamorelin considered selective compared to other GHRPs?

A: Earlier GHRP compounds such as GHRP-2 and GHRP-6 co-stimulate ACTH and cortisol release in addition to GH. Research indicates Ipamorelin produces minimal co-stimulation of these axes at GH-effective concentrations, making it a cleaner research tool for isolating GH secretion mechanisms.

Q: Is Ipamorelin for human use?

A: No. Ipamorelin supplied by Biovantage Labs is strictly for laboratory research purposes. It is not approved for human consumption, veterinary use, or clinical application.

Q: What purity standard does Biovantage Labs apply?

A: Every batch is verified at 99+% purity using HPLC to confirm compound concentration and Mass Spectrometry to confirm molecular identity. Batch-specific COA documentation is available upon request.

Q: Where does Biovantage Labs ship from?

A: All Biovantage Labs products are fulfilled domestically from within Canada, eliminating customs clearance risk and reducing transit time compared to international suppliers.