Description

Tesamorelin Biovantage Labs Research Peptide

Tesamorelin is a stabilised synthetic analogue of growth hormone releasing hormone (GHRH) studied for its stimulation of endogenous GH secretion and its role in visceral adipose tissue regulation research models. Biovantage Labs supplies Tesamorelin at 99+% purity, verified by batch-specific HPLC and Mass Spectrometry. Domestically fulfilled from Canada. Not for human consumption. Biovantage Labs provides this compound at 99+% purity, confirmed by batch-specific HPLC and Mass Spectrometry analysis, as a lyophilized compound for use in controlled laboratory settings.

Molecular Profile and Chemical Specifications

Specification	Detail
Molecular Formula	C221H366N72O67S1
Molecular Weight	5,135.8 Da
Structure	Trans-3-hexenoic acid conjugated GHRH(1-44) analogue
Purity	≥99+% (HPLC/MS verified)
Physical Form	Lyophilized white powder
CAS Number	218949-48-5

 

Primary Research Mechanisms

GHRH Receptor Activation and GH Secretion

Tesamorelin activates the GHRH receptor on anterior pituitary somatotrophs with affinity comparable to native GHRH. The trans-3-hexenoic acid modification at the N-terminus provides resistance to dipeptidyl peptidase IV (DPP-IV) degradation, extending functional half-life in research models.

Comparative GHRH analogue research frequently positions Tesamorelin alongside CJC-1295 with DAC, both activate the GHRH receptor but employ different stabilisation strategies, and the pharmacokinetic differences between DPP-IV resistance and albumin binding are themselves a subject of research interest.

Visceral Adipose Tissue Research

Tesamorelin is studied in models examining the relationship between GH axis stimulation and visceral fat depot regulation. Research in this area examines the metabolic consequences of GH-driven lipolysis specifically within visceral compartments.

IGF-1 and Lipid Metabolism Pathways

Downstream of GH stimulation, Tesamorelin research examines effects on IGF-1 expression and circulating lipid profiles, including triglyceride levels in preclinical and clinical study designs.

For visceral adipose tissue research protocols, AOD-9604 represents a mechanistically distinct approach, derived from the C-terminal HGH fragment and studied for direct beta-3 adrenergic lipolytic activity independent of the GHRH receptor pathway examined in Tesamorelin research.

Reconstitution Protocol

• Reconstitute using sterile bacteriostatic water or 0.9% sodium chloride solution
• Introduce diluent slowly along the interior vial wall. Do not inject directly onto the lyophilized cake
• Swirl gently until fully dissolved. Do not shake or vortex
• Allow the vial to equilibrate to room temperature before opening to prevent condensation

Storage and Stability

Storage Condition	State	Estimated Stability
-20°C to -80°C	Lyophilized	24+ months
2°C to 8°C	Lyophilized	12 months
Room temperature (20°C)	Lyophilized	3 months
2°C to 8°C	Reconstituted	7 to 14 days

 

Store in a desiccated environment away from UV exposure. Avoid repeated freeze-thaw cycles, which degrade peptide chain integrity over time.

Tesamorelin Research FAQ

Q: What structural modification makes Tesamorelin more stable than native GHRH?

A: The trans-3-hexenoic acid conjugation at the N-terminus of GHRH(1-44) confers resistance to DPP-IV enzymatic cleavage, which rapidly degrades native GHRH. This modification extends the effective research window without altering the peptide’s receptor binding profile.

Q: Is Tesamorelin for human use?

A: No. Tesamorelin supplied by Biovantage Labs is strictly for laboratory research purposes. It is not approved for human consumption, veterinary use, or clinical application.

Q: What purity standard does Biovantage Labs apply?

A: Every batch is verified at 99+% purity using HPLC to confirm compound concentration and Mass Spectrometry to confirm molecular identity. Batch-specific COA documentation is available upon request.

Q: Where does Biovantage Labs ship from?

A: All Biovantage Labs products are fulfilled domestically from within Canada, eliminating customs clearance risk and reducing transit time compared to international suppliers.