Description

IGF-1 LR3 Biovantage Labs Research Peptide

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a recombinant analogue of IGF-1 with an N-terminal extension and Arg3 substitution, studied for reduced IGF binding protein affinity and extended half-life in cell proliferation, differentiation, and anabolic signalling research models. Biovantage Labs supplies IGF-1 LR3 at 99+% purity, HPLC/MS verified. Domestically fulfilled from Canada. Not for human consumption. Biovantage Labs provides this compound at 99+% purity, confirmed by batch-specific HPLC and Mass Spectrometry analysis, as a lyophilized compound for use in controlled laboratory settings.

Molecular Profile and Chemical Specifications

Specification	Detail
Molecular Formula	C400H625N111O115S9
Molecular Weight	9,111 Da
Modifications	13-AA N-terminal extension; Arg3 substitution (reduces IGFBP-3 affinity ~500-fold)
Purity	≥99+% (HPLC/MS verified)
Physical Form	Lyophilized white powder
CAS Number	946870-92-4

 

Primary Research Mechanisms

IGF-1 Receptor Activation and PI3K-Akt-mTOR Signalling

IGF-1 LR3 binds the IGF-1 receptor (IGF1R) with affinity comparable to native IGF-1, activating the PI3K-Akt-mTOR cascade. Research examining this pathway investigates downstream regulation of protein synthesis, cell cycle progression, and anti-apoptotic signalling.

IGF-1 LR3 is frequently used as a direct receptor-level tool in research protocols that also examine HGH (Human Growth Hormone), allowing investigators to distinguish between GH-mediated hepatic IGF-1 production and direct IGF-1 receptor activation as separate variables in anabolic signalling research.

IGFBP Displacement and Extended Bioavailability Research

The Arg3 substitution dramatically reduces IGF-1 LR3’s affinity for IGF binding proteins (IGFBPs), which normally sequester approximately 95% of circulating IGF-1. Research using LR3 versus native IGF-1 allows investigation of free versus bound IGF-1 contributions to receptor signalling in cell culture and animal models.

Skeletal Muscle and Satellite Cell Research

IGF-1 LR3’s extended bioavailability makes it a preferred research tool for studying IGF-1 receptor-mediated satellite cell activation and myoblast proliferation in skeletal muscle models, where native IGF-1’s rapid IGFBP sequestration limits experimental control.

Skeletal muscle hypertrophy research examining the IGF-1 axis is often designed alongside myostatin pathway inhibition studies using Follistatin-344, allowing comparative investigation of anabolic signalling through IGF-1R versus TGF-beta pathway blockade.

Reconstitution Protocol

• Reconstitute using sterile bacteriostatic water or 0.9% sodium chloride solution
• Introduce diluent slowly along the interior vial wall do not inject directly onto the lyophilized cake
• Swirl gently until fully dissolved do not shake or vortex
• Allow the vial to equilibrate to room temperature before opening to prevent condensation

Storage and Stability

Storage Condition	State	Estimated Stability
-20°C to -80°C	Lyophilized	24+ months
2°C to 8°C	Lyophilized	12 months
Room temperature (20°C)	Lyophilized	3 months
2°C to 8°C	Reconstituted	7 to 14 days

 

Store in a desiccated environment away from UV exposure. Avoid repeated freeze-thaw cycles, which degrade peptide chain integrity over time.

IGF-1 LR3 Research FAQ

Q: How does the half-life of IGF-1 LR3 compare to native IGF-1 in research models?

A: Native IGF-1 has a half-life of minutes when free and hours when IGFBP-bound. IGF-1 LR3’s reduced IGFBP affinity results in a plasma half-life of approximately 20 to 30 hours in rodent models a significant extension that allows sustained receptor engagement in longer experimental protocols.

Q: Is IGF-1 LR3 for human use?

A: No. IGF-1 LR3 supplied by Biovantage Labs is strictly for laboratory research purposes. It is not approved for human consumption, veterinary use, or clinical application.

Q: What purity standard does Biovantage Labs apply?

A: Every batch is verified at 99+% purity using HPLC to confirm compound concentration and Mass Spectrometry to confirm molecular identity. Batch-specific COA documentation is available upon request.

Q: Where does Biovantage Labs ship from?

A: All Biovantage Labs products are fulfilled domestically from within Canada, eliminating customs clearance risk and reducing transit time compared to international suppliers.