Description

MOTS-c Biovantage Labs Research Peptide

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid mitochondria-derived peptide encoded within the mitochondrial genome a structurally distinct class from nuclear-encoded peptides. Its primary research significance lies in its role as a metabolic regulator, with particular focus on AMPK pathway activation, glucose homeostasis, and mitochondrial stress response signalling.

Biovantage Labs supplies MOTS-c in two research configurations 10mg and 40mg at 99+% purity, confirmed by batch-specific HPLC and Mass Spectrometry, for use in controlled laboratory settings.

Molecular Profile and Chemical Specifications

Primary Research Mechanisms

MOTS-c is studied across metabolic, mitochondrial, and longevity research contexts. Its mitochondrial origin distinguishes its signalling properties from conventional nuclear-encoded peptides.

Mitochondrial longevity research examining both signalling and structural aspects of mitochondrial function may position MOTS-c alongside SS-31 (Elamipretide). MOTS-c studied for AMPK pathway activation and nuclear stress response signalling, SS-31 for cardiolipin stabilisation and electron transport chain structural integrity.

AMPK Pathway Activation and Glucose Homeostasis

The most well-characterised research pathway for MOTS-c involves activation of AMP-activated protein kinase (AMPK), a central metabolic sensor. In skeletal muscle models, MOTS-c has been shown to stimulate AMPK phosphorylation, promoting glucose uptake independent of insulin a mechanism with significant implications for metabolic research.

Mitochondrial Stress Response and Nuclear Translocation

Under conditions of mitochondrial stress, MOTS-c translocates from the mitochondria to the nucleus, where it modulates gene expression involved in cellular stress adaptation. This nucleus-directed activity positions MOTS-c as a subject of research in mitochondrial-nuclear communication and cellular resilience.

Folate Cycle Interference via AICAR Accumulation

MOTS-c inhibits the folate cycle through accumulation of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), an endogenous AMPK activator. This pathway is studied in the context of one-carbon metabolism and its downstream effects on nucleotide synthesis and methylation processes.

Longevity and Age-Related Research Models

MOTS-c circulating levels decline with age in both animal and human subject studies. This pattern has positioned it as a candidate compound in longevity research models examining the relationship between mitochondrial signalling and biological ageing processes.

MOTS-c’s AMPK activation research intersects with NAD+ biology at the cellular energy-sensing level. AMPK and sirtuin pathways are both regulated by cellular energy status, and research examining MOTS-c’s metabolic effects is often designed alongside NAD+ availability studies to characterise the relationship between mitochondrial signalling and coenzyme pool dynamics.

Selecting the Correct Research Configuration

Reconstitution Protocol

• Reconstitute using sterile bacteriostatic water or 0.9% sodium chloride solution
• Introduce diluent slowly along the interior vial wall do not inject directly onto the lyophilized cake
• Swirl gently until fully dissolved do not shake or vortex
• Allow the vial to equilibrate to room temperature before opening to prevent condensation

Storage and Stability

Store in a desiccated environment away from UV exposure. Avoid repeated freeze-thaw cycles.

MOTS-c Research FAQ

Q: What distinguishes MOTS-c from other mitochondria-derived peptides?

A: MOTS-c is encoded within the mitochondrial genome rather than nuclear DNA, placing it in a distinct class of peptides. Its capacity for nuclear translocation under stress conditions makes it a subject of interest in research examining mitochondrial-nuclear signalling as a discrete regulatory axis.

Q: Why does Biovantage Labs offer MOTS-c in two configurations?

A: The 10mg configuration supports pilot studies and dose-response work where compound conservation matters. The 40mg configuration serves extended research protocols and multi-cohort designs. Both are produced to the same 99+% purity standard.

Q: What purity standard does Biovantage Labs apply to MOTS-c?

A: Every batch is verified at 99+% purity using HPLC to confirm compound concentration and Mass Spectrometry to confirm molecular identity. Batch-specific COA documentation is available upon request.

Q: Is MOTS-c for human use?

A: No. MOTS-c supplied by Biovantage Labs is strictly for laboratory research purposes. It is not approved for human consumption, veterinary use, or clinical application.