Description

NAD+ Biovantage Labs Research Peptide

NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme studied for its central role in cellular energy metabolism, sirtuin activation, DNA repair signalling, and mitochondrial function research models. Biovantage Labs supplies NAD+ at 99+% purity, verified by batch-specific HPLC and Mass Spectrometry. Domestically fulfilled from Canada. Not for human consumption. Biovantage Labs provides this compound at 99+% purity, confirmed by batch-specific HPLC and Mass Spectrometry analysis, as a lyophilized compound for use in controlled laboratory settings.

Molecular Profile and Chemical Specifications

Specification	Detail
Molecular Formula	C21H27N7O14P2
Molecular Weight	663.4 Da
Classification	Coenzyme – oxidised form
Purity	≥99+% (HPLC/MS verified)
Physical Form	Lyophilized white powder
CAS Number	53-84-9

 

Primary Research Mechanisms

Sirtuin Activation and Epigenetic Regulation

NAD+ is an obligate co-substrate for sirtuin deacylases (SIRT1-7). Research examining sirtuin-mediated deacetylation of histones, transcription factors, and metabolic enzymes depends on NAD+ availability. Declining NAD+ levels are a focus of ageing research precisely because they limit sirtuin activity.

Research examining NAD+ availability from a supply-side perspective may also include 5-Amino-1MQ, an NNMT inhibitor that preserves nicotinamide (the direct NAD+ precursor) by blocking its methylation, representing a mechanistically upstream approach to the same NAD+ pool management research question.

PARP-Dependent DNA Repair Research

Poly(ADP-ribose) polymerases (PARPs) consume NAD+ during DNA damage detection and repair signalling. NAD+ is studied in the context of PARP-mediated genome maintenance and the relationship between NAD+ pool depletion and reduced DNA repair capacity in ageing models.

Mitochondrial Electron Transport Chain Function

As the principal electron carrier in cellular respiration, NAD+/NADH cycling is fundamental to ATP production via the mitochondrial electron transport chain. Research using NAD+ examines its role in mitochondrial bioenergetics under normal and stress conditions.

Cellular redox homeostasis research examining NAD+/NADH cycling alongside antioxidant defence systems frequently includes Glutathione as the primary non-enzymatic antioxidant reference compound, allowing investigation of the relationship between oxidative phosphorylation efficiency and intracellular GSH/GSSG status.

Reconstitution Protocol

• Reconstitute using sterile bacteriostatic water or 0.9% sodium chloride solution
• Introduce diluent slowly along the interior vial wall do not inject directly onto the lyophilized cake
• Swirl gently until fully dissolved do not shake or vortex
• Allow the vial to equilibrate to room temperature before opening to prevent condensation

Storage and Stability

Storage Condition	State	Estimated Stability
-20°C to -80°C	Lyophilized	24+ months
2°C to 8°C	Lyophilized	12 months
Room temperature (20°C)	Lyophilized	3 months
2°C to 8°C	Reconstituted	7 to 14 days

 

Store in a desiccated environment away from UV exposure. Avoid repeated freeze-thaw cycles, which degrade peptide chain integrity over time.

NAD+ Research FAQ

Q: How does direct NAD+ differ from NAD+ precursor research approaches?

A: NAD+ precursors such as NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are converted intracellularly to NAD+ via the salvage pathway. Direct NAD+ research bypasses precursor conversion steps, allowing investigation of cellular uptake mechanisms and the relationship between extracellular NAD+ availability and intracellular metabolic outcomes.

Q: Is NAD+ for human use?

A: No. NAD+ supplied by Biovantage Labs is strictly for laboratory research purposes. It is not approved for human consumption, veterinary use, or clinical application.

Q: What purity standard does Biovantage Labs apply?

A: Every batch is verified at 99+% purity using HPLC to confirm compound concentration and Mass Spectrometry to confirm molecular identity. Batch-specific COA documentation is available upon request.

Q: Where does Biovantage Labs ship from?

A: All Biovantage Labs products are fulfilled domestically from within Canada, eliminating customs clearance risk and reducing transit time compared to international suppliers.