Description

ACE-031 – 1mg Lyophilized Powder

ACE-031 is a soluble fusion protein investigated for its role in the regulation of muscle mass and bone density. As a recombinant therapeutic candidate, it consists of a portion of the human Activin Receptor Type IIB (ActRIIB) fused to the Fc portion of human IgG1. In laboratory environments, ACE-031 is researched for its ability to bind to ligands like Myostatin (GDF-8) and Activin A, preventing them from signaling through endogenous receptors. This makes it a primary tool for studying the inhibition of catabolic pathways in skeletal muscle.

Technical Specifications 

Competitive Inhibition of Myostatin and ActRIIB Ligands

The science of ACE-031 centers on its function as a “decoy” receptor. Naturally, Myostatin and Activin A bind to the ActRIIB receptor on the surface of muscle cells to limit growth and maintain muscle homeostasis. ACE-031 is researched for its ability to intercept these ligands before they reach the cell membrane. By sequestering these proteins, researchers can observe the subsequent upregulation of protein synthesis and the suppression of the Smad2/3 signaling pathway. For laboratories utilizing peptides in Canada, ACE-031 provides a specialized model for investigating muscular dystrophy, sarcopenia, and the metabolic impact of increased lean tissue mass.

Protocols for Large Protein Stability

Because ACE-031 is a large fusion protein rather than a simple short-chain peptide, it is significantly more sensitive to mechanical and thermal stress.

• Reconstitution: Use sterile bacteriostatic water or sterile saline. Do not vibrate or shake the vial. Allow the diluent to run down the side of the glass and let it sit undisturbed until fully dissolved to prevent protein aggregation.
• Stability: This reagent is highly sensitive. Once reconstituted, it should be kept refrigerated at 2°C–8°C and used within 7–10 days for maximum potency.
• Shipping: Performance Peptides Canada utilizes specialized lyophilization to ensure the tertiary structure of the protein remains intact during domestic transit.