Description

AOD-9604 (Anti-Obesity Drug-9604) is a synthetic peptide analogue of the C-terminal fragment of human growth hormone (HGH), specifically residues 177-191. Unlike full-length HGH, AOD-9604 is designed to isolate the lipolytic (fat-burning) properties of the hormone while omitting the somatogenic (growth-promoting) and insulin-antagonistic effects. In laboratory research, it is the primary entity for investigating the regulation of lipid metabolism and chondrocyte repair.

 

Performance Peptides Canada offers AOD-9604 50mg vials at 99%+ HPLC-verified purity. Our domestic fulfillment ensures that researchers receive laboratory-grade ligands optimized for studying metabolic flux and adipose tissue reduction without compromising glycemic control.

Technical Specifications & Chemical Architecture

Our AOD-9604 is synthesized to the following analytical benchmarks:

• Molecular Formula: C₇₈H₁₂₃N₂₃O₂₃S₂ ​
• Molecular Weight: 1815.08 g/mol
• Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
• Modification: Disulfide bridge between Cys7 and Cys14 for structural stability.
• Purity: ≥99.0% (Verified via HPLC/MS)
• Form: Lyophilized white powder

Primary Research Mechanisms & Metabolic Utility

AOD-9604 is studied for its ability to mimic the way natural growth hormone regulates fat metabolism.

1. Stimulation of Lipolysis

AOD-9604 stimulates the breakdown of triglycerides into free fatty acids and glycerol. Research suggests that it acts primarily on beta3-adrenergic receptors in white adipose tissue, increasing the activity of hormone-sensitive lipase (HSL). This makes it a critical tool for investigating targeted adipose reduction.

2. Inhibition of Lipogenesis

Beyond burning existing fat, AOD-9604 is investigated for its ability to inhibit lipogenesis, the process by which non-fatty food sources are converted into body fat. Researchers utilize this peptide to study the prevention of new fat cell formation, particularly in models of metabolic syndrome.

3. Chondrogenic & Orthopedic Potential

Interestingly, research has expanded into the field of regenerative medicine. AOD-9604 is studied for its potential to stimulate the proliferation of chondrocytes and enhance the repair of damaged cartilage. It is frequently used in orthopedic research models involving osteoarthritis and tendon repair.

Reconstitution & Stability Benchmarks

AOD-9604 is relatively stable, but its disulfide bridge requires careful handling to maintain potency:

• Reconstitution: Recommended diluent is Bacteriostatic Water or 0.9% Sterile Saline.
• Solubility: AOD-9604 can occasionally be difficult to dissolve at high concentrations. If the solution is cloudy, a small drop of acetic acid (10%) may be used to clear the solution, though usually, gentle swirling is sufficient.
• Storage: Store lyophilized powder at -20°C. Once reconstituted, store at 2°C to 8°C.

Stability Data

Storage Condition	Physical State	Estimated Stability
-20°C (Freezer)	Lyophilized (Dry)	24+ Months
2°C to 8°C (Fridge)	Lyophilized (Dry)	12 Months
2°C to 8°C (Fridge)	Reconstituted	7–14 Days

AOD-9604 Research FAQ

Q: Does AOD-9604 affect blood sugar?

A: Unlike full-length HGH, AOD-9604 does not compete with insulin for its receptor. Research indicates it does not raise blood glucose levels or contribute to insulin resistance, making it a safer entity for studying long-term metabolic changes.

 

Q: What is the difference between AOD-9604 and Fragment 176-191?

A: AOD-9604 is a slightly modified version of the 176-191 fragment (specifically, an added tyrosine at the N-terminus). This modification was designed to increase the peptide’s stability and absorption profile compared to the standard 176-191 fragment.

 

Q: Is your AOD-9604 shipped within Canada?

A: Yes. Performance Peptides Canada fulfills all orders domestically. This is essential for maintaining the cold chain and ensuring that the peptide’s disulfide bonds remain intact during transit.