Description

ACE-031 Biovantage Labs Research Peptide

ACE-031 is a soluble form of activin receptor type IIB (ACVR2B) fused to an IgG1 Fc domain, studied as a myostatin and GDF ligand trap in skeletal muscle mass research models. Biovantage Labs supplies ACE-031 at 99+% purity, HPLC/MS verified. Domestically fulfilled from Canada. Not for human consumption. Biovantage Labs provides this compound at 99+% purity, confirmed by batch-specific HPLC and Mass Spectrometry analysis, as a lyophilized compound for use in controlled laboratory settings.

Molecular Profile and Chemical Specifications

Specification	Detail
Classification	ACVR2B-Fc fusion protein – TGF-beta ligand trap
Purity	≥99+% (HPLC/MS verified)
Physical Form	Lyophilized white powder

 

Primary Research Mechanisms

ACE-031 and Follistatin-344 are studied in the same skeletal muscle hypertrophy research context but through structurally distinct mechanisms. ACE-031, as a decoy receptor-Fc fusion, sequesters multiple TGF-beta ligands through a receptor binding approach, and Follistatin-344, as a secreted glycoprotein, binds the same ligands through direct protein-protein interaction. Comparative research between the two tools examines whether the mechanism of antagonism influences research outcomes independently of the degree of pathway blockade.

Broad TGF-beta Ligand Sequestration

ACE-031’s ACVR2B domain binds multiple TGF-beta superfamily ligands including myostatin (GDF-8), activin A/B, GDF-11, and BMP-9 preventing their engagement with endogenous receptors. This broad ligand trap activity is studied in muscle wasting and atrophy research models.

Skeletal Muscle Mass and Fibre Type Research

ACVR2B-mediated TGF-beta signalling suppresses muscle anabolism via SMAD2/3. Research using ACE-031 examines the consequences of broad ligand sequestration on muscle fibre cross-sectional area, fibre type composition, and functional strength outcomes in animal models.

Comparison with Myostatin-Specific Inhibition

ACE-031’s multi-ligand activity profile distinguishes it from myostatin-specific inhibitors. Research comparing ACE-031 with myostatin-selective approaches investigates the additive or synergistic contributions of activin and GDF-11 blockade beyond isolated myostatin inhibition.

For research examining dual-pathway skeletal muscle anabolism, IGF-1 LR3 represents the complementary anabolic research axis, promoting muscle satellite cell proliferation and PI3K-Akt-mTOR signalling through IGF-1 receptor engagement, in contrast to ACE-031’s TGF-beta ligand sequestration approach.

Reconstitution Protocol

• Reconstitute using sterile bacteriostatic water or 0.9% sodium chloride solution
• Introduce diluent slowly along the interior vial wall do not inject directly onto the lyophilized cake
• Swirl gently until fully dissolved do not shake or vortex
• Allow the vial to equilibrate to room temperature before opening to prevent condensation

Storage and Stability

Storage Condition	State	Estimated Stability
-20°C to -80°C	Lyophilized	24+ months
2°C to 8°C	Lyophilized	12 months
Room temperature (20°C)	Lyophilized	3 months
2°C to 8°C	Reconstituted	7 to 14 days

 

Store in a desiccated environment away from UV exposure. Avoid repeated freeze-thaw cycles, which degrade peptide chain integrity over time.

ACE-031 Research FAQ

Q: How does ACE-031 differ from Follistatin-344 as a myostatin antagonist?

A: Follistatin-344 is a secreted glycoprotein that binds activins and myostatin through direct protein-protein interaction. ACE-031 is a biologically engineered receptor-Fc fusion that sequesters the same ligands through a decoy receptor mechanism. Both result in reduced ACVR2B signalling but via distinct structural approaches, making them complementary research tools.

Q: Is ACE-031 for human use?

A: No. ACE-031 supplied by Biovantage Labs is strictly for laboratory research purposes. It is not approved for human consumption, veterinary use, or clinical application.

Q: What purity standard does Biovantage Labs apply?

A: Every batch is verified at 99+% purity using HPLC to confirm compound concentration and Mass Spectrometry to confirm molecular identity. Batch-specific COA documentation is available upon request.

Q: Where does Biovantage Labs ship from?

A: All Biovantage Labs products are fulfilled domestically from within Canada, eliminating customs clearance risk and reducing transit time compared to international suppliers.