Description

Semax Biovantage Labs Research Peptide

Semax is a synthetic heptapeptide analogue of the ACTH(4-7) fragment studied for its neuroprotective properties, BDNF upregulation, and dopaminergic system modulation in neurological research models. Biovantage Labs supplies Semax at 99+% purity, verified by batch-specific HPLC and Mass Spectrometry. Domestically fulfilled from Canada. Not for human consumption. Biovantage Labs provides this compound at 99+% purity, confirmed by batch-specific HPLC and Mass Spectrometry analysis, as a lyophilized compound for use in controlled laboratory settings.

Molecular Profile and Chemical Specifications

Specification	Detail
Molecular Formula	C37H51N9O10S
Molecular Weight	813.9 Da
Sequence	Met-Glu-His-Phe-Pro-Gly-Pro (ACTH(4-7) PGP analogue)
Purity	≥99+% (HPLC/MS verified)
Physical Form	Lyophilized white powder
CAS Number	80714-61-0

 

Primary Research Mechanisms

BDNF Upregulation and Neurotrophin Signalling

Semax has been studied for its capacity to upregulate brain-derived neurotrophic factor (BDNF) and its receptor TrkB in hippocampal and cortical research models. BDNF signalling is a primary focus of neuroplasticity and neuroprotection research.

Semax and Selank are the two most widely studied ACTH-derived synthetic peptides in nootropic research, often examined together in protocols investigating complementary neurochemical profiles, Semax’s dopaminergic and BDNF-focused activity alongside Selank’s GABAergic and serotonergic modulation properties.

Dopaminergic and Serotonergic Pathway Modulation

Neurochemical research has examined Semax’s influence on dopamine and serotonin turnover in rodent brain models. Studies have investigated changes in monoamine metabolite profiles following Semax administration as markers of neurotransmitter system engagement.

Ischaemia and Neuroprotection Models

Semax has been studied in cerebral ischaemia models for its capacity to reduce infarct volume and preserve neurological function markers. Research in this area examines anti-apoptotic and anti-inflammatory mechanisms in neural tissue.

Neuroprotection research comparing single-peptide and multicomponent neurotrophic approaches frequently positions Semax alongside Cerebrolysin. Cerebrolysin’s complex mixture of BDNF-, NGF-, and NT-3-mimicking peptide fractions provides a contrasting research profile to Semax’s defined heptapeptide mechanism.

Reconstitution Protocol

• Reconstitute using sterile bacteriostatic water or 0.9% sodium chloride solution
• Introduce diluent slowly along the interior vial wall do not inject directly onto the lyophilized cake
• Swirl gently until fully dissolved do not shake or vortex
• Allow the vial to equilibrate to room temperature before opening to prevent condensation

Storage and Stability

Storage Condition	State	Estimated Stability
-20°C to -80°C	Lyophilized	24+ months
2°C to 8°C	Lyophilized	12 months
Room temperature (20°C)	Lyophilized	3 months
2°C to 8°C	Reconstituted	7 to 14 days

 

Store in a desiccated environment away from UV exposure. Avoid repeated freeze-thaw cycles, which degrade peptide chain integrity over time.

Semax Research FAQ

Q: How is Semax structurally related to ACTH?

A: Semax is based on the ACTH(4-7) fragment (Met-Glu-His-Phe) with an added Pro-Gly-Pro extension that confers resistance to enzymatic degradation. The parent ACTH(4-7) sequence has demonstrated neurological activity in research models, and the Pro-Gly-Pro modification is designed to extend its research utility by improving molecular stability.

Q: Is Semax for human use?

A: No. Semax supplied by Biovantage Labs is strictly for laboratory research purposes. It is not approved for human consumption, veterinary use, or clinical application.

Q: What purity standard does Biovantage Labs apply?

A: Every batch is verified at 99+% purity using HPLC to confirm compound concentration and Mass Spectrometry to confirm molecular identity. Batch-specific COA documentation is available upon request.

Q: Where does Biovantage Labs ship from?

A: All Biovantage Labs products are fulfilled domestically from within Canada, eliminating customs clearance risk and reducing transit time compared to international suppliers.