Description

Glutathione (GSH) is a vital tripeptide (gamma-L-Glutamyl-L-cysteinylglycine) that serves as the centerpiece of cellular defense. In its reduced state, it acts as the primary electron donor to neutralize reactive oxygen species (ROS) and maintain the redox environment of the cell. The 1500mg format is an advanced research concentration, providing the necessary volume for high-dose investigations into hepatic Phase II conjugation, mitochondrial membrane preservation, and the systemic mitigation of cytokine-induced oxidative stress.

Performance Peptides Canada offers Glutathione in professional 1500mg vials, verified at 99%+ purity via HPLC. Our domestic Canadian fulfillment ensures that this high-capacity antioxidant remains in its stable, reduced form, bypassing the oxidation risks associated with international transit.

Technical Specifications & Chemical Profile

Our 1500mg Glutathione is synthesized to rigorous analytical standards:

• Molecular Formula: C₁₀H₁₇N₃O₆S
• Molecular Weight: 307.32 g/mol5
• Chemical Name: (2S)-2-amino-5-[[(1R)-1-[(carboxymethyl)amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid
• Purity: ≥99.0% (Verified via HPLC/MS)6
• CAS Number: 70-18-87
• Physical Form: Lyophilized white crystalline powder

Primary Research Mechanisms at High Concentrations

The 1500mg dosage allows for specialized research into the kinetics of glutathione depletion and replenishment.

1. Saturation of Glutathione S-Transferase (GST)

Researchers utilize high-dose GSH to study the saturation points of Glutathione S-transferase, the enzyme family responsible for conjugating GSH to electrophilic compounds. This is critical for researching the clearance of environmental toxins, heavy metals, and metabolic byproducts that require high availability of reduced sulfur groups for excretion.

2. Preservation of Mitochondrial DNA (mtDNA)

High concentrations of GSH are studied for their ability to traverse the mitochondrial membrane via specific carriers (DIC and OGC). By maintaining high intramitochondrial GSH levels, researchers can observe the protection of mitochondrial DNA against superoxide radicals generated during the Electron Transport Chain (ETC) cycle.

3. Synergistic Redox Recycling

Glutathione does not act in isolation. It is the engine that recycles other antioxidants. High-dose GSH research often looks at the “Redox Couple” efficiency, specifically how GSH reduces oxidized Vitamin C (dehydroascorbic acid) and Vitamin E (tocopheroxyl radical) back into their active, functional states.

Reconstitution & Handling Protocols

With a 1500mg mass in a single vial, reconstitution requires precise laboratory technique to ensure full solubility without oxidation:

• Reconstitution: Recommended diluent is Bacteriostatic Water or 0.9% Sterile Saline. Due to the high mass, 5mL to 10mL of diluent is recommended for a standard research concentration.
• Solubility: High-purity GSH is highly soluble. Gently swirl the vial; avoid vigorous shaking to prevent the introduction of atmospheric oxygen into the solution.
• pH Stability: Reconstituted GSH is slightly acidic. If your research model is pH-sensitive, ensure the diluent or buffer accounts for this shift.

Stability Data

Pro Tip: Because 1500mg is a large quantity, researchers often aliquot the solution into smaller, airtight, light-protected vials immediately after reconstitution to prevent the “spent” oxidation of the entire batch during repeated use.

Glutathione 1500mg Research FAQ

Q: Is this the “Reduced” or “Oxidized” form?

A: This is Reduced L-Glutathione (GSH). This is the only form capable of active antioxidant work. The oxidized form (GSSG) is essentially a byproduct and is not used for primary antioxidant research.

Q: Why use 1500mg instead of 600mg?

A: The 1500mg vial is designed for high-demand research protocols, such as investigating systemic oxidative stress models or large-scale in-vitro studies, providing better batch consistency and value for high-volume needs.

Q: Does it ship from Canada?

A: Yes. Performance Peptides Canada fulfills all 1500mg Glutathione orders domestically. High-dose GSH is sensitive to heat-induced oxidation; our fast domestic shipping ensures the material arrives in its optimal reduced state.