Description

MOTS-C 10mg is available at Performance Peptides Canada for qualified Canadian researchers. Each batch is HPLC-verified at 99%+ purity with a Certificate of Analysis included with every order. MOTS-C (Mitochondrial ORF of the 12S rRNA-c) is a 16-amino-acid peptide encoded by the mitochondrial genome, studied in non-clinical laboratory research for its role in AMPK pathway activation, metabolic homeostasis, and mitochondrial-to-nuclear signalling under conditions of cellular stress. All products sold by Performance Peptides Canada are strictly for laboratory and research use only and are not intended for human consumption, medical use, or diagnostic applications.

MOTS-c is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S ribosomal RNA gene. Unlike traditional hormones, MOTS-c acts as a “mitokine,” translocating to the nucleus in response to metabolic stress to regulate nuclear gene expression. In laboratory research, it is the primary entity for investigating the mitochondrial-nuclear communication axis and its impact on systemic metabolism and cellular aging.

 

Performance Peptides Canada provides MOTS-c 10mg vials at 99%+ HPLC-verified purity. Our domestic Canadian fulfillment ensures that this sensitive metabolic regulator is shipped with speed and climate integrity for advanced mitochondrial research.

Technical Specifications & Chemical Profile

Our MOTS-c is synthesized to the following analytical benchmarks:

• Molecular Formula: C₇₈H₁₃₈N₂₆O₂₄S₂
• Molecular Weight: 2174.6 g/mol3
• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Met-Cys-Ser-Ser-Asp-Ala
• Purity: ≥99.0% (Verified via HPLC/MS)
• CAS Number: 1627580-64-64
• Form: Lyophilized white powder

Primary Research Mechanisms & Metabolic Regulation

MOTS-c is studied for its unique ability to mimic the beneficial effects of exercise at a cellular level.

1. AMPK Activation & Glucose Metabolism

MOTS-c is a potent activator of the AMP-activated protein kinase (AMPK) pathway. By increasing the levels of AICAR (an intermediate in the purine salvage pathway), MOTS-c enhances glucose uptake in skeletal muscle and inhibits gluconeogenesis in the liver. Researchers utilize this peptide to study the restoration of insulin sensitivity and the reversal of diet-induced metabolic dysfunction.

2. Mitochondrial-Nuclear Translocation

Under conditions of metabolic stress (such as exercise or nutrient deprivation), MOTS-c translocates from the mitochondria to the nucleus. There, it interacts with ARE (Antioxidant Response Element)-containing genes to regulate the cellular stress response. This unique “retrograde signaling” is a vital area of study for researchers interested in mitohormesis and genomic stability.

3. Fatty Acid Oxidation & Thermogenesis

Research indicates that MOTS-c promotes the beta-oxidation of fatty acids and influences the “browning” of white adipose tissue. By upregulating UCP1 (Uncoupling Protein 1), it is studied for its role in increasing thermogenesis and whole-body energy expenditure, making it an essential tool for obesity and lipid metabolism research.

Reconstitution & Stability Benchmarks

As a mitochondrial-derived peptide, MOTS-c is highly sensitive to pH and temperature:

• Reconstitution: Recommended diluent is Bacteriostatic Water or 0.9% Sterile Saline.
• Solubility: MOTS-c is generally well-dissolved in aqueous solutions, but may require gentle swirling. Do not shake, as mechanical stress can lead to peptide aggregation.
• Storage: Store lyophilized powder at -20°C. Once reconstituted, store at 2°C to 8°C.

Stability Data

Storage Condition	Physical State	Estimated Stability
-20°C (Freezer)	Lyophilized (Dry)	24+ Months
2°C to 8°C (Fridge)	Lyophilized (Dry)	12 Months
2°C to 8°C (Fridge)	Reconstituted	5–7 Days

Note: For maximal potency in research, it is recommended to use MOTS-c shortly after reconstitution, as mitochondrial peptides can be more susceptible to enzymatic degradation than standard signaling peptides.

MOTS-c Research FAQ

Q: Is MOTS-c considered an “exercise mimetic”?

A: Yes. In research models, MOTS-c has been shown to produce metabolic changes similar to those induced by aerobic exercise, including improved glucose disposal and increased mitochondrial biogenesis.

 

Q: What is the purity of your MOTS-c?

A: Every batch of MOTS-c 10mg from Performance Peptides Canada is verified to be 99% pure or higher via HPLC and Mass Spectrometry.

 

Q: Why is domestic Canadian shipping important for MOTS-c?

A: MOTS-c is a complex peptide that requires stable environmental conditions. Shipping from within Canada avoids the extreme temperature fluctuations and customs delays that can occur with international orders, ensuring the peptide arrives in its most active form.

 

Q: Is MOTS-C legal to purchase in Canada?

A: MOTS-C is sold in Canada strictly as a research reagent for qualified laboratory and non-clinical research use. It is not approved by Health Canada for human use, is not a licensed drug, and is not intended for consumption or therapeutic application. MOTS-C is listed on the World Anti-Doping Agency (WADA) Prohibited List under category S0 as a non-approved substance, which restricts its use by competitive athletes. All orders from Performance Peptides Canada are supplied under a research-use-only framework.

 

Q: What purity standard does Performance Peptides Canada use for MOTS-C?

A: Every batch of MOTS-C 10mg supplied by Performance Peptides Canada is HPLC-verified at 99%+ purity. A batch-specific Certificate of Analysis is included with every order, allowing Canadian researchers to independently verify compound identity and purity data before use in laboratory applications.

 

Q: How is MOTS-C shipped within Canada?

A: MOTS-C orders are fulfilled domestically from within Canada, eliminating customs delays and cross-border handling. Orders ship as lyophilised powder in sealed research-grade vials. Domestic fulfillment means researchers receive their orders faster and without the uncertainty of international customs clearance.

 

Q: What makes MOTS-C different from other mitochondrial-derived peptides?

A: MOTS-C is one of three identified mitochondrial-derived peptides, alongside humanin and the SHLP family. Its primary distinguishing characteristic in the research literature is its ability to translocate from the mitochondria to the nucleus under metabolic stress conditions, where it directly regulates nuclear gene expression through antioxidant response elements. This mitochondrial-to-nuclear signalling behaviour is what separates MOTS-C mechanistically from humanin and makes it a distinct research subject in the study of metabolic homeostasis and cellular stress adaptation.