Description

Selank is a synthetic analogue of the naturally occurring tetrapeptide Tuftsin, modified with a Pro-Gly-Pro sequence at the C-terminus to enhance metabolic stability and prolong its biological activity. As a regulatory heptapeptide, Selank is a primary entity in the study of neurobiology, specifically regarding its influence on the central nervous system (CNS) and its ability to modulate the body’s response to environmental stressors.

Performance Peptides Canada provides Selank 10mg vials at 99%+ HPLC-verified purity. Our domestic fulfillment ensures that researchers receive a stable, laboratory-grade compound optimized for studying anxiolytic pathways and cognitive homeostasis.

Technical Specifications & Chemical Profile

Our Selank is synthesized to rigorous analytical standards to ensure reproducibility in laboratory settings:

• Molecular Formula: C₃₃H₅₇N₁₁O₉
• Molecular Weight: 751.9 g/mol
• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
• CAS Number: 129954-34-3
• Purity: ≥99.0% (Verified via HPLC/MS)
• Form: Lyophilized white powder

Primary Research Mechanisms & Neuro-Modulation

Selank is distinguished from other neuro-peptides by its specific interactions with neurotransmitter systems and inflammatory markers.

1. GABAergic System Modulation

In neurochemical research, Selank is investigated for its role as an allosteric modulator of GABA (Gamma-aminobutyric acid) receptors. Unlike traditional benzodiazepines, Selank appears to influence the affinity of GABA for its receptors without the sedative or addictive properties, making it an essential tool for studying “clean” anxiolytic mechanisms.

2. BDNF & Neurotrophic Signaling

Experimental models utilize Selank to study the expression of Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus. BDNF is critical for neuronal survival, growth, and plasticity. By upregulating neurotrophin levels, Selank provides a pathway for researching neuro-restoration and cognitive enhancement under conditions of chronic stress.

3. Immunomodulatory Properties

Selank is unique for its “neuro-immunomodulatory” effects. It is studied for its ability to regulate the balance of Th1/Th2 cytokines and influence the levels of Interleukin-6 (IL-6). This makes it a vital entity for investigating the link between systemic inflammation and psychiatric conditions.

Reconstitution & Stability Benchmarks

Selank is highly stable due to its Pro-Gly-Pro modification, but laboratory best practices should still be observed:

• Reconstitution: Recommended for use with Bacteriostatic Water or Sterile Saline.
• Storage: For long-term integrity, store lyophilized powder at -20°C. Once reconstituted, keep refrigerated at 2°C to 8°C.
• Stability: In its reconstituted state, Selank maintains high stability for up to 30 days when properly refrigerated and protected from UV light.

Selank Research FAQ

Q: What is the difference between Selank and Semax?

A: While both are derived from natural peptides and feature the PGP stabilizing sequence, they serve different research purposes. Semax is primarily studied for its stimulating, cognitive-enhancing (nootropic) effects, whereas Selank is investigated for its regulatory, calming (anxiolytic) properties and its impact on the immune system.

Q: Is Selank batch-tested?

A: Yes. Performance Peptides Canada provides batch-specific HPLC and Mass Spectrometry reports for every 10mg vial to confirm a purity level of at least 99%.

Q: How do you ship Selank within Canada?

A: We use secure, temperature-monitored domestic shipping. By shipping from within Canada, we ensure that your Selank is not subject to the lengthy delays or temperature fluctuations common with international customs processing.