Description

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) that serves as a stabilized analogue of the ACTH(4-10) fragment. Originally developed for the treatment of acute neuro-metabolic disorders, Semax is a primary entity in modern neuroscience research. It is investigated for its profound neuroprotective and nootropic properties, operating through the modulation of neurotrophic factors and neurotransmitter systems without the hormonal side effects of full-length Adrenocorticotropic hormone.

Performance Peptides Canada offers Semax 10mg vials at 99%+ purity. Every batch is verified via HPLC and Mass Spectrometry to ensure the structural integrity of the Pro-Gly-Pro stabilizing sequence, essential for prolonged biological activity in Canadian laboratory settings.

Technical Specifications & Chemical Profile

Our Semax is synthesized to the following analytical benchmarks:

• Molecular Formula: C₃₇H₅₁N₉O₁₀S
• Molecular Weight: 813.92 g/mol
• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
• Purity: ≥99.0% (Verified via HPLC/MS)
• CAS Number: 80714-61-0
• Form: Lyophilized white powder

Primary Research Mechanisms & Neuro-Enhancement

Semax is studied for its multi-faceted approach to brain health, primarily focusing on neuroplasticity and cellular survival.

1. BDNF & TrkB Receptor Activation

One of the most significant areas of Semax research involves its impact on Brain-Derived Neurotrophic Factor (BDNF). Studies suggest that Semax upregulates the expression of BDNF and its primary receptor, TrkB, in the hippocampus and frontal cortex. This pathway is critical for investigating synaptogenesis, long-term potentiation (LTP), and the restoration of cognitive function following metabolic insult.

2. Melanocortin System Interaction

Semax is an agonist for the Melanocortin receptors (MC4R). Unlike traditional stimulants, it influences the CNS through these receptors to improve focus, mental clarity, and attention span. Researchers utilize Semax to study the non-hormonal benefits of melanocortin signaling on executive function and stress resilience.

3. Modulation of mRNA Expression

At the genomic level, Semax is studied for its ability to change the expression of genes involved in the immune response and vascular regulation. Research indicates it may influence the expression of VEGF (Vascular Endothelial Growth Factor), facilitating improved cerebral blood flow and oxygenation in models of neuro-ischemia.

Reconstitution & Stability Benchmarks

Semax is uniquely stable due to its C-terminal Pro-Gly-Pro sequence, which protects it from rapid enzymatic breakdown, but it still requires standard peptide handling:

• Reconstitution: Recommended diluents include Bacteriostatic Water or 0.9% Sterile Saline.
• Technique: Gently introduce 2-3mL of diluent down the glass wall. Swirl slowly; do not shake or agitate.
• Storage: Store lyophilized powder at -20°C. Once reconstituted, Semax is notably more stable than other neuro-peptides, but should still be kept refrigerated at 2°C to 8°C.

Stability Data

Semax Research FAQ

Q: Is Semax the same as Selank?

A: No. While both are “nootropic” peptides developed through similar research programs, they have different effects. Semax is studied for its stimulating, focus-enhancing, and neuro-regenerative properties. Selank is studied for its anxiolytic (calming) and immunomodulatory effects.

Q: Why is the “Pro-Gly-Pro” sequence important?

A: This specific sequence at the end of the Semax chain acts as a biological “shield.” It makes the peptide highly resistant to protease enzymes in the blood and brain, allowing for a significantly longer half-life compared to the original ACTH(4-10) fragment.

Q: Does Performance Peptides Canada ship Semax domestically?

A: Yes. All Semax orders are shipped from our Canadian facilities. This ensures the cold chain is maintained and eliminates the risk of customs delays, which is vital for maintaining the efficacy of neuro-research materials.