Description
Thymosin Alpha-1 is a synthetic version of a naturally occurring 28-amino acid peptide derived from the thymus gland. In molecular biology, Tα1 is classified as a biological response modifier (BRM) and is researched for its potent immunomodulatory effects. Unlike traditional immunosuppressants, Tα1 is studied for its ability to restore immune homeostasis by enhancing T-cell maturation and modulating the release of pro-inflammatory cytokines. This makes it a cornerstone reagent for investigating viral pathogenesis, chronic inflammation, and vaccine adjuvant efficiency.
Technical Specifications
| Feature | Specification |
| Molecular Formula | C129H215N33O55 |
| Molecular Weight | 3108.3 g/mol |
| Sequence | Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH |
| Purity | 99%+ (Analytical Grade) |
| Format | Lyophilized White Powder |
| Storage | -20°C (Long-term) |
T-Cell Differentiation and MHC Class I Expression
The scientific significance of Thymosin Alpha-1 lies in its interaction with Toll-like receptors (TLRs), specifically TLR-9 and TLR-2, on dendritic cells. Research suggests that Tα1 promotes the differentiation of pluripotent stem cells into CD4+/CD8+ T-cells, the primary effectors of the adaptive immune system.
Furthermore, Tα1 is researched for its ability to increase the expression of MHC Class I molecules, making virally infected or malignant cells more “visible” to the immune system. For laboratories utilizing peptides in Canada, this compound offers a robust model for studying the reversal of immune senescence and the optimization of the Th1 immune response.
Analytical Stability and Storage Protocols
Thymosin Alpha-1 is a highly stable peptide when kept in its lyophilized form, but it requires precise handling once reconstituted to maintain its 28-amino acid structural integrity.
- Reconstitution: Reconstitute with sterile bacteriostatic water. Allow the liquid to flow down the side of the vial to minimize foaming.
- Stability: Reconstituted Tα1 is stable for up to 14 days when refrigerated at 2°C–8°C. For experiments requiring longer durations, aliquoting and freezing at -20°C is recommended to prevent repeated freeze-thaw cycles.
- Domestic Integrity: Performance Peptides Canada ensures all Tα1 vials are nitrogen-flushed and vacuum-sealed, protecting the peptide from oxidation during transit across the Canadian climate.
Reviews
There are no reviews yet.