Description

Epithalon – Prometheus Labs Research Peptide

Epithalon (Epitalon) is a synthetic tetra-peptide consisting of four amino acids (Ala-Glu-Asp-Gly) modeled after the naturally occurring peptide Epithalamin, produced in the pineal gland. In the field of gerontology and cellular biology, Epithalon is the primary entity studied for its ability to overcome the Hayflick Limit by influencing the enzymatic activity of telomerase.

Prometheus Labs provides Epithalon at 50mg per vial, 99%+ HPLC-verified purity. Our domestic Canadian fulfillment ensures that researchers receive laboratory-grade ligands with the chemical stability required for precise investigation into cellular senescence and telomere elongation.

Technical Specifications & Chemical Architecture

Our Epithalon is synthesized to the following analytical benchmarks:

• Molecular Formula: C14H22N4O9
• Molecular Weight: 390.35 g/mol
• Sequence: Ala-Glu-Asp-Gly (L-Alanyl-L-glutamyl-L-aspartyl-glycine)
• CAS Number: 307297-39-8
• Purity: ≥99.0% (Verified via HPLC/MS)
• Vial Size: 50mg
• Form: Lyophilized white powder

(These values matched between what was already live and standard published data for Epithalon, no discrepancy flagged here, unlike the dose field.)

Primary Research Mechanisms & Cellular Impact

Epithalon is distinguished by its direct interaction with the genetic machinery of the cell, specifically regarding chromosomal stability.

1. Telomerase Activation & Telomere Elongation

The most documented mechanism of Epithalon is its ability to induce the expression of the telomerase reverse transcriptase (TERT) gene. By activating the telomerase enzyme, Epithalon allows for the elongation of telomeres, the protective caps at the ends of chromosomes. Researchers utilize this 50mg format to study the potential for reversing cellular senescence and extending the proliferative lifespan of cell cultures.

2. Pineal Gland & Melatonin Regulation

As an analogue of Epithalamin, Epithalon is studied for its regulatory effect on the pineal gland. Research suggests it can restore the sensitivity of the pineal gland to light/dark cycles and normalize the production of endogenous melatonin, making it a vital entity for investigating circadian rhythm restoration and neuroendocrine health in aging models.

This pineal-regulatory role is distinct from other pineal-derived bio-regulators such as Pinealon, which shares the same tissue origin but is studied primarily for neuro-regeneration and epigenetic gene regulation rather than telomerase activity. 

3. Antioxidant & DNA Repair Pathways

Epithalon is investigated for its scavenging capabilities against free radicals. By upregulating antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase, it is studied for its role in protecting DNA from oxidative damage and reducing the incidence of chromosomal aberrations.

This antioxidant research parallels work on SS-31, a mitochondria-targeted peptide studied for reducing oxidative stress at the mitochondrial membrane rather than at the nuclear/chromosomal level.

Reconstitution & Stability Benchmarks

Despite being a short-chain tetra-peptide with high stability, Epithalon should be handled using standard laboratory protocols:

• Reconstitution: Recommended diluent is Bacteriostatic Water or 0.9% Sterile Saline.
• Storage: Store lyophilized powder at -20°C for long-term preservation. Once reconstituted, store at 2°C to 8°C.
• Stability: Reconstituted Epithalon remains stable for approximately 14–21 days when refrigerated. Protect from direct UV exposure to prevent photodegradation of the peptide bonds.

Epithalon Research FAQ

Q: How does Epithalon differ from Epithalamin?

A: Epithalamin is the natural peptide extract from the pineal gland, containing a mix of peptides. Epithalon is the specific, synthetic 4-amino acid sequence identified as the primary active component responsible for telomerase activation.

Q: What is the purity level of your Epithalon?

A: We guarantee a purity of 99% or higher. Every batch of Epithalon 50mg is tested via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to confirm its chemical identity and purity.

Q: Where does Performance Peptides Canada ship from?

A: All orders are fulfilled domestically from within Canada. This ensures your research is not interrupted by the risks of international shipping, such as customs seizures or prolonged exposure to unregulated temperatures.