Description

SS-31 Biovantage Labs Research Peptide

SS-31 (Elamipretide) is a mitochondria-targeted tetrapeptide studied for its interactions with cardiolipin, mitochondrial inner membrane integrity, and electron transport chain efficiency in cardiac and skeletal muscle research models. Biovantage Labs supplies SS-31 in 10mg and 50mg configurations at 99+% purity, HPLC/MS verified. Domestically fulfilled from Canada. Not for human consumption. Biovantage Labs provides this compound at 99+% purity, confirmed by batch-specific HPLC and Mass Spectrometry analysis, as a lyophilized compound for use in controlled laboratory settings.

Molecular Profile and Chemical Specifications

Specification	Detail
Molecular Formula	C32H52N12O5
Molecular Weight	688.8 Da
Sequence	D-Arg-Dmt-Lys-Phe-NH2
Purity	≥99+% (HPLC/MS verified)
Physical Form	Lyophilized white powder
Available Configurations	10mg / 50mg
CAS Number	736992-21-5

 

Selecting the Correct Research Configuration

Configuration	Typical Research Application
10mg	Pilot studies, dose-response investigations, shorter experimental timelines
50mg	Extended protocols, multi-cohort studies, higher-throughput laboratory settings

 

Primary Research Mechanisms

Cardiolipin Interaction and Mitochondrial Membrane Stabilisation

SS-31 selectively concentrates in the inner mitochondrial membrane, where it binds cardiolipin, a phospholipid critical for maintaining electron transport chain complex organisation and cristae structure. Research examines whether this interaction prevents cardiolipin peroxidation and preserves mitochondrial membrane potential under stress conditions.

Mitochondrial function research often positions SS-31 alongside MOTS-c to examine complementary mitochondrial protective mechanisms. SS-31 targeting cardiolipin stability at the inner membrane, while MOTS-c is studied for its role in AMPK activation and mitochondrial stress-responsive nuclear translocation.

Electron Transport Chain Efficiency Research

By stabilising cardiolipin and cristae architecture, SS-31 is studied for its effects on electron transport chain complex assembly and efficiency. Research in this area measures ATP production rates and mitochondrial oxygen consumption as functional readouts.

Cardiac and Renal Ischaemia-Reperfusion Research

SS-31 has been examined in ischaemia-reperfusion injury models in cardiac and renal tissues, where mitochondrial dysfunction is a primary driver of cell death. Research examines whether SS-31 pretreatment or co-administration modifies tissue damage markers and mitochondrial recovery outcomes.

For research examining the relationship between mitochondrial membrane integrity and bioenergetic output, NAD+ is studied as the electron carrier whose pool size and availability are directly affected by electron transport chain efficiency, a parameter that SS-31’s cardiolipin-stabilising mechanism is studied to modulate.

Reconstitution Protocol

•  Reconstitute using sterile bacteriostatic water or 0.9% sodium chloride solution
• Introduce diluent slowly along the interior vial wall do not inject directly onto the lyophilized cake
• Swirl gently until fully dissolved do not shake or vortex
• Allow the vial to equilibrate to room temperature before opening to prevent condensation

Storage and Stability

Storage Condition	State	Estimated Stability
-20°C to -80°C	Lyophilized	24+ months
2°C to 8°C	Lyophilized	12 months
Room temperature (20°C)	Lyophilized	3 months
2°C to 8°C	Reconstituted	7 to 14 days

 

Store in a desiccated environment away from UV exposure. Avoid repeated freeze-thaw cycles, which degrade peptide chain integrity over time.

SS-31 Research FAQ

Q: Why does SS-31 concentrate in mitochondria specifically?

A: SS-31 carries an overall net positive charge (3+) due to its arginine and lysine residues, and contains alternating aromatic and cationic groups that confer affinity for the highly negatively charged cardiolipin-rich inner mitochondrial membrane. This selective accumulation estimated at 1,000-fold concentration relative to cytoplasm in some models is the basis of its mitochondria-targeted research utility.

Q: Is SS-31 for human use?

A: No. SS-31 supplied by Biovantage Labs is strictly for laboratory research purposes. It is not approved for human consumption, veterinary use, or clinical application.

Q: What purity standard does Biovantage Labs apply?

A: Every batch is verified at 99+% purity using HPLC to confirm compound concentration and Mass Spectrometry to confirm molecular identity. Batch-specific COA documentation is available upon request.

Q: Where does Biovantage Labs ship from?

A: All Biovantage Labs products are fulfilled domestically from within Canada, eliminating customs clearance risk and reducing transit time compared to international suppliers.