Description

Thymosin Alpha-1 – Prometheus Labs Research Peptide

Thymosin Alpha-1 is a synthetic version of a naturally occurring 28-amino acid peptide derived from the thymus gland. In molecular biology, Tα1 is classified as a biological response modifier (BRM) and is researched for its potent immunomodulatory effects. Unlike traditional immunosuppressants, Tα1 is studied for its ability to restore immune homeostasis by enhancing T-cell maturation and modulating the release of pro-inflammatory cytokines, making it a cornerstone reagent for investigating viral pathogenesis, chronic inflammation, and vaccine adjuvant efficiency.

Prometheus Labs supplies Thymosin Alpha-1 at 99%+ analytical grade purity, available in 1mg and 2mg vials. Our domestic Canadian fulfillment ensures researchers receive stable, verified reagents for precise immunological investigation.

Technical Specifications

Feature	Specification
Molecular Formula	C129H215N33O55
Molecular Weight	3108.32 g/mol
Sequence	Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
CAS Number	62304-98-7
Purity	99%+ (Analytical Grade)
Form	Lyophilized white powder
Storage	-20°C (long-term)

(No Additional Information tab needed once the incorrect 793.92 g/mol entry is removed, this table already covers everything accurately.)

T-Cell Differentiation and MHC Class I Expression

The scientific significance of Thymosin Alpha-1 lies in its interaction with Toll-like receptors (TLRs), specifically TLR-9 and TLR-2, on dendritic cells. Research suggests that Tα1 promotes the differentiation of pluripotent stem cells into CD4+/CD8+ T-cells, the primary effectors of the adaptive immune system. Tα1 is also researched for its ability to increase the expression of MHC Class I molecules, making virally infected or malignant cells more visible to the immune system, offering a robust model for studying the reversal of immune senescence and the optimization of the Th1 immune response.

This adaptive immune modulation role is distinct from innate immune signalling research such as LL-37, which acts through FPR2-mediated neutrophil and monocyte chemotaxis rather than T-cell maturation.

Reconstitution and Stability Protocols

Thymosin Alpha-1 is a highly stable peptide when kept in its lyophilized form, but requires precise handling once reconstituted:

• Reconstitution: Reconstitute with sterile bacteriostatic water, allow the liquid to flow down the side of the vial to minimize foaming
• Stability: Reconstituted Tα1 is stable for up to 14 days when refrigerated at 2°C-8°C; aliquoting and freezing at -20°C is recommended for longer durations
• Domestic Integrity: Performance Peptides Canada ensures all Tα1 vials are nitrogen-flushed and vacuum-sealed, protecting the peptide from oxidation during transit

Thymosin Alpha-1 Research FAQ

Q: What’s the difference between Thymosin Alpha-1 and Thymosin Beta-4/TB-500?

A: Thymosin Alpha-1 acts on adaptive immune signalling via T-cell maturation and TLR interaction. TB-500 (Thymosin Beta-4) is studied for actin-regulation and tissue repair, a distinct mechanism entirely, despite sharing “thymosin” nomenclature.

Q: What purity standard applies?

A: 99%+ analytical grade, confirmed via HPLC/MS. Batch-specific COA documentation available upon request.

Q: Where does Performance Peptides Canada ship from?

A: All Performance Peptides Canada products are fulfilled domestically within Canada.