Description

5-AMINO-1MQ Biovantage Labs Research Peptide

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule NNMT (Nicotinamide N-methyltransferase) inhibitor studied for its effects on NAD+ precursor availability, adipocyte metabolism, and cellular energy regulation research models. Biovantage Labs supplies 5-Amino-1MQ at 99+% purity, HPLC/MS verified. Domestically fulfilled from Canada. Not for human consumption. Biovantage Labs provides this compound at 99+% purity, confirmed by batch-specific HPLC and Mass Spectrometry analysis, as a lyophilized compound for use in controlled laboratory settings.

Molecular Profile and Chemical Specifications

Specification	Detail
Molecular Formula	C10H10N2
Molecular Weight	158.2 Da
Classification	NNMT inhibitor
Purity	≥99+% (HPLC/MS verified)
Physical Form	Lyophilized white powder
CAS Number	2222306-63-8

 

Primary Research Mechanisms

NNMT Inhibition and SAM/SAH Ratio Modulation

5-Amino-1MQ inhibits Nicotinamide N-methyltransferase, the enzyme responsible for methylating nicotinamide using S-adenosylmethionine (SAM). Inhibition preserves SAM availability and reduces S-adenosylhomocysteine (SAH) accumulation, altering the methyl donor balance in cellular research models.

The mechanistic connection between 5-Amino-1MQ and NAD+ biology is direct; NNMT inhibition preserves nicotinamide availability for the NAD+ salvage pathway. Research examining this relationship often uses NAD+ as a direct comparison tool to investigate cellular energy metabolism outcomes achievable through precursor preservation versus direct NAD+ administration.

NAD+ Precursor Pathway Research

By reducing NNMT-mediated nicotinamide consumption, 5-Amino-1MQ is studied for its capacity to increase nicotinamide availability for NAD+ biosynthesis via the salvage pathway a mechanism relevant to research on cellular energy metabolism and sirtuin activation.

Adipocyte Metabolism and Fat Cell Size Research

In adipocyte research models, NNMT inhibition by 5-Amino-1MQ has been associated with reductions in lipid accumulation and adipocyte hypertrophy. This research examines the relationship between one-carbon metabolism and fat cell biology.

For metabolic research examining AMPK activation alongside NNMT inhibition, MOTS-c, a mitochondria-derived peptide studied for AMPK pathway activation and glucose homeostasis, represents a complementary research tool targeting the same downstream metabolic energy-sensing pathway through an upstream mitochondrial mechanism.

Reconstitution Protocol

•       Reconstitute using sterile bacteriostatic water or 0.9% sodium chloride solution
•       Introduce diluent slowly along the interior vial wall do not inject directly onto the lyophilized cake
•       Swirl gently until fully dissolved do not shake or vortex
•       Allow the vial to equilibrate to room temperature before opening to prevent condensation

Storage and Stability

Storage Condition	State	Estimated Stability
-20°C to -80°C	Lyophilized	24+ months
2°C to 8°C	Lyophilized	12 months
Room temperature (20°C)	Lyophilized	3 months
2°C to 8°C	Reconstituted	7 to 14 days

 

Store in a desiccated environment away from UV exposure. Avoid repeated freeze-thaw cycles, which degrade peptide chain integrity over time.

5-AMINO-1MQ Research FAQ

Q: How does 5-Amino-1MQ relate to NAD+ research?

A: NNMT consumes nicotinamide a direct NAD+ precursor through methylation. By inhibiting NNMT, 5-Amino-1MQ preserves nicotinamide availability for the NAD+ salvage pathway. This makes it a complementary research tool to direct NAD+ precursors like NMN and NR, approaching the same metabolic pathway from a different mechanistic angle.

Q: Is 5-AMINO-1MQ for human use?

A: No. 5-AMINO-1MQ supplied by Biovantage Labs is strictly for laboratory research purposes. It is not approved for human consumption, veterinary use, or clinical application.

Q: What purity standard does Biovantage Labs apply?

A: Every batch is verified at 99+% purity using HPLC to confirm compound concentration and Mass Spectrometry to confirm molecular identity. Batch-specific COA documentation is available upon request.

Q: Where does Biovantage Labs ship from?

A: All Biovantage Labs products are fulfilled domestically from within Canada, eliminating customs clearance risk and reducing transit time compared to international suppliers.